Antidiabetic properties of Prickly Pear (Opuntia Ficus-Indica) fruit extract

Authors

Kenzy Aidan Joseph McKay, The American University in CairoFollow

Abstract

Diabetes mellitus is a metabolic disorder that claims 1.5 million lives annually. Opuntia ficus-indica, commonly known as the prickly pear, has been commonly used in traditional folk medicine for its hypoglycemic properties. It has been claimed that it has antimicrobial and antioxidant properties as well. The plant is native to Mexico and is commonly found in the middle east and India and folk medicine from all of these areas have been using prickly pear medicinally for years. To test these claims an extract of locally sourced Opuntia ficus-indica was prepared using the flesh and seeds of the fruit. The extract was analyzed via GC-MS to identify its bioactive compounds. The extract was tested in vitro using the L929 fibroblast cell line for cytotoxicity and oxidative stress effects including anti-inflammatory and antioxidant properties. The antidiabetic effects were tested on STZ induced rats in comparison to current commercial treatment, Metformin. The results show anti-diabetic, anti-inflammatory and antioxidant properties in Opuntia Ficus-indica as well as potential hepatoprotective properties. It also performed better than metformin in lowering blood sugar and protecting against heart disease and other diabetic comorbidities. Overall it shows good potential for use in treatment of Diabetes mellitus and its comorbidities either as a standalone treatment or in conjunction with current treatments.

Document Type

Research Article

Department

Biology Department

Recommended Citation

McKay, Kenzy Aidan Joseph (2025) "Antidiabetic properties of Prickly Pear (Opuntia Ficus-Indica) fruit extract," The Undergraduate Research Journal: Vol. 10, Article 11.
Available at: https://fount.aucegypt.edu/urje/vol10/iss1/11

Institutional Review Board (IRB) Approval

Not necessary for this item