Recent progress on polySarcosine as an alternative to PEGylation: Synthesis and biomedical applications

Funding Number

01DL20003

Funding Sponsor

Arab-German Young Academy of Sciences and Humanities

Author's Department

Chemistry Department

Second Author's Department

Chemistry Department

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https://doi.org/10.1016/j.ijpharm.2024.123871

All Authors

Mohamed Fawzi Kabil, Hassan Mohamed El Said Azzazy, Maha Nasr

Document Type

Research Article

Publication Title

International Journal of Pharmaceutics

Publication Date

3-25-2024

doi

10.1016/j.ijpharm.2024.123871

Abstract

Biotherapeutic PEGylation to prolong action of medications has gained popularity over the last decades. Various hydrophilic natural polymers have been developed to tackle the drawbacks of PEGylation, such as its accelerated blood clearance and non-biodegradability. Polypeptoides, such as polysarcosine (pSar), have been explored as hydrophilic substitutes for PEG. pSar has PEG-like physicochemical characteristics such as water solubility and no reported cytotoxicity and immunogenicity. This review discusses pSar derivatives, synthesis, characterization approaches, biomedical applications, in addition to the challenges and future perspectives of pSar based biomaterials as an alternative to PEG.

Comments

Review. Record derived from SCOPUS.

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