How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials
Funding Number
403224013 – SFB 1382- A05
Funding Sponsor
Deutsche Forschungsgemeinschaft
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https://doi.org/10.1016/j.tifs.2021.11.004
Document Type
Research Article
Publication Title
Trends in Food Science and Technology
Publication Date
12-1-2021
doi
10.1016/j.tifs.2021.11.004
Abstract
Background: The gut microbiome has become a hot topic in recent years with increasing reports on the positive role of a well-balanced gut microbiota composition for one's health and well-being. A number of dietary factors can modulate gut composition, although few publications have focused on common daily beverages impact on the gut microbiome. Coffee is a worldwide beverage consumed mostly as black coffee that is originally derived from green coffee beans post roasting. To enhance the taste and aroma, green coffee is typically roasted and to further affect its chemical composition and rationalize for the different health outcomes. Roasted seeds contain a high caffeine levels versus phenolic acids i.e., chlorogenic acid enrichment in green coffee suggestive that they interact differently with gut microbiota and to affect its metabolism. Scope and approach: The present review provides a mechanistic insight on the effects of black and green coffee chemicals on the gut microbiome. We present herein the first comprehensive review of how coffee natural bioactive such as caffeine and chlorogenic acid and its process derived chemicals i.e., melanoidins can specifically influence gut homeostasis, and likewise via gut microbiota-mediated coffee chemicals metabolism. Key findings and conclusions: The role of gut microbiota in affecting coffee chemicals and the potential of mining metagenomics data to uncover gut microbiome community and carbohydrate active enzyme (CAZyme) profile associated with coffee consumption are presented for the first time. Moreover, our metagenomics analysis in silico showed a decrease in abundance in either Desulfofarcimen or Mycoplasma genera, confirmed the basic coffee-gut microbial enzymes repertoire found in the literature and highlights for the first time the coffee CAZyme biomarkers encoded by the human gut microbiome.
First Page
920
Last Page
937
Recommended Citation
APA Citation
Farag, M.
von Bergen, M.
Saleh, B.
Homsi, M.
&
Abd El-Al, M.
(2021). How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials. Trends in Food Science and Technology, 118, 920–937.
10.1016/j.tifs.2021.11.004
https://fount.aucegypt.edu/faculty_journal_articles/2577
MLA Citation
Farag, Mohamed A., et al.
"How do green and black coffee brews and bioactive interaction with gut microbiome affect its health outcomes? Mining evidence from mechanistic studies, metagenomics and clinical trials." Trends in Food Science and Technology, vol. 118, 2021, pp. 920–937.
https://fount.aucegypt.edu/faculty_journal_articles/2577