A global metagenomic map of urban microbiomes and antimicrobial resistance
Funding Number
11140666
Funding Sponsor
National Science Foundation
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https://doi.org/10.1016/j.cell.2021.05.002
Document Type
Research Article
Publication Title
Cell
Publication Date
6-24-2021
doi
10.1016/j.cell.2021.05.002
Abstract
We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
First Page
3376
Last Page
3393.e17
Recommended Citation
APA Citation
Danko, D.
Bezdan, D.
Afshin, E.
Ahsanuddin, S.
...
(2021). A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell, 184(13), 3376–3393.e17.
10.1016/j.cell.2021.05.002
https://fount.aucegypt.edu/faculty_journal_articles/2499
MLA Citation
Danko, David, et al.
"A global metagenomic map of urban microbiomes and antimicrobial resistance." Cell, vol. 184,no. 13, 2021, pp. 3376–3393.e17.
https://fount.aucegypt.edu/faculty_journal_articles/2499