Abstract

Marine algae are a rich source of biologically active compounds such as sulfated polysaccharides, lipids, proteins, carotenoids and polyphenols, that can be used in food, cosmetic, nutraceutical and pharmaceutical industries due to their antioxidant, anticancer, antibacterial, and anticoagulant activities. In the present study, ultrasound-assisted extraction was performed on the red algae Pterocladia capillacea. The extraction procedure was optimized to maximize yield and total carbohydrate content. The extract was shown to possess potent antioxidant activity and was successfully used as a reducing and capping agent in the green synthesis of copper nanoparticles. The synthesized copper nanoparticles were characterized by UV-spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS). The produced nanoparticles constituted primarily CuO and they had an average size of 62.5 nm. FTIR spectra for the extract and copper nanoparticles synthesized from the algal extract showed characteristic peaks of polysaccharides. The synthesized copper nanoparticles were subsequently loaded with nedaplatin. UV data suggested that the mixture resulted in complex formation. Nedaplatin release profiles showed sustained release reaching a maximum at 120 h. The formulation was shown to have greater cytotoxic profiles relative to nedaplatin on hepatocellular carcinoma, breast cancer and ovarian cancer cell lines.

School

School of Sciences and Engineering

Department

Chemistry Department

Degree Name

MS in Chemistry

Graduation Date

Spring 5-31-2020

Submission Date

5-31-2020

First Advisor

Shoeib, Tamer

Second Advisor

EL-Sayyed, Mayyada

Committee Member 1

Tallima, Hatem

Committee Member 2

Abdel-Nasser, Anwar

Committee Member 3

Saleh, Nermin

Extent

99 p.

Document Type

Master's Thesis

Rights

The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy. The author has granted the American University in Cairo or its agents a non-exclusive license to archive this thesis, dissertation, paper, or record of study, and to make it accessible, in whole or in part, in all forms of media, now or hereafter known.

Institutional Review Board (IRB) Approval

Not necessary for this item

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