Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting
Author's Department
Chemistry Department
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https://doi.org/10.1016/j.ijpharm.2017.06.044
Document Type
Research Article
Publication Title
International Journal of Pharmaceutics
Publication Date
8-30-2017
doi
10.1016/j.ijpharm.2017.06.044
Abstract
© 2017 A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using 125I isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using γ-rays, Ag-based radioiodo-NPs with a maximum labeling yield were intravenously injected in normal and solid tumor bearing mice. The preliminary biodistribution study revealed that this new radioiodo-NPs have a high affinity to be localized in the tumor site for a long period of time. The reported highly efficient method provides new radiolabeled Ag-based NPs as tumor-specific agents for both diagnostic and therapeutic applications.
First Page
123
Last Page
133
Recommended Citation
APA Citation
Farrag, N.
El-Sabagh, H.
Al-mahallawi, A.
Amin, A.
...
(2017). Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting. International Journal of Pharmaceutics, 529(1-2), 123–133.
10.1016/j.ijpharm.2017.06.044
https://fount.aucegypt.edu/faculty_journal_articles/978
MLA Citation
Farrag, Nourihan S., et al.
"Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting." International Journal of Pharmaceutics, vol. 529,no. 1-2, 2017, pp. 123–133.
https://fount.aucegypt.edu/faculty_journal_articles/978