Gut microbial shifts toward inflammation in Parkinson's disease: Insights from pilot shotgun metagenomics Egyptian cohort

Author's Department

Biology Department

Second Author's Department

Institute of Global Health & Human Ecology

Third Author's Department

Institute of Global Health & Human Ecology

Fifth Author's Department

Institute of Global Health & Human Ecology

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https://doi.org/10.1177/1877718X251370156

All Authors

Ali Shalash Shahd Ezzeldin Sara Hashish Yara Salah Noha L. Dawood Ahmed Moustafa Mohamed Salama

Document Type

Letter to the Editor

Publication Title

Journal of Parkinson S Disease

Publication Date

12-1-2025

doi

10.1177/1877718X251370156

Abstract

Gut microbiome alterations are increasingly linked to Parkinson's disease (PD), yet regional signatures remain underexplored. We performed shotgun metagenomic sequencing of stool samples from Egyptian PD patients and healthy controls. PD patients exhibited depletion of short-chain fatty acid-producing taxa, and enrichment of pathobionts. Our findings suggested a pro-inflammatory gut shift in PD and emphasized the need for geographically diverse microbiome studies. While limited in sample size (n = 7 PD patients and n = 6 controls), this pilot addressed a critical gap in African PD microbiome research.

First Page

1540

Last Page

1543

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