Sofosbuvir: A comprehensive profile

Funding Sponsor

American University in Cairo

Author's Department

Chemistry Department

Second Author's Department

Chemistry Department

Third Author's Department

Chemistry Department

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https://doi.org/10.1016/bs.podrm.2024.10.003

All Authors

Jude Majed Lababidi Mohamed Fawzy Kabil Hassan Mohamed El Said Azzazy

Document Type

Research Article

Publication Title

Profiles of Drug Substances Excipients and Related Methodology

Publication Date

1-1-2025

doi

10.1016/bs.podrm.2024.10.003

Abstract

Sofosbuvir, a nucleotide analogue, is an antiviral medication that belongs to the class of direct-acting antivirals (DAAs). It is primarily used in the treatment of chronic hepatitis C virus (HCV) infections. Sofosbuvir works by inhibiting the replication of HCV, disrupting its ability to produce RNA and effectively reducing the viral load in the body. This chapter offers a comprehensive examination of sofosbuvir, including its nomenclature, physiochemical attributes, synthesis, and thermal analysis. Furthermore, it presents various analytical methods employed for both spectrophotometric and chromatographic assessments of sofosbuvir in different matrices.

First Page

1

Last Page

41

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