Actively targeted hyperbranched metal organic framework-based core-shell nanocarriers for the treatment of breast cancer
Funding Sponsor
Science and Technology Development Fund
Author's Department
Biology Department
Third Author's Department
Biology Department
Fourth Author's Department
Biology Department
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https://doi.org/10.1039/d5tb00505a
Document Type
Research Article
Publication Title
Journal of Materials Chemistry B
Publication Date
8-27-2025
doi
10.1039/d5tb00505a
Abstract
Active-targeted nanocarriers are increasingly deployed for the precise and efficacious delivery of chemotherapeutic drugs to treat breast cancer (BC). This study portrays a BC-directed core-shell drug delivery system (DDS), where the core is made of a highly porous, biocompatible and drug accommodating metal organic framework, NH2-MIL-101(Fe) MOF. Hence, the core is covalently linked with the hyperbranched dendrimer, G0.5-PAMAM. PAMAM confers multiple modifiable termini that are further functionalized with glutathione (GSH) as a targeting moiety. The prepared nanosystem (MPG) underwent physicochemical characterization using FTIR, 1H-NMR, and PXRD, indicating the successful fabrication of the designed DDS. Additionally, TEM micrographs depicted an octahedral core with a size range of 100-150 nm. The assessed surface charge was +21 ± 0.2 indicating proper functionalization and colloidal stability of MPG. Besides, doxorubicin (DOX)-loaded MPG exhibited an entrapment efficiency of 65.3 ± 3% along with enhanced drug release in acidic medium. In addition, in vitro biological assays demonstrated that DOX-MPG possessed selective antiproliferative activity towards breast carcinoma cells (MCF-7) over normal cells (L929). Additionally, treatment with DOX-MPG efficiently induced apoptosis and G2/M cell cycle arrest in MCF7 cells. Finally, in vivo biological studies proved the therapeutic efficacy of DOX-MPG in mammary gland tumor-bearing mice. Conclusively, our findings suggest that the designed DDS offers a versatile platform for the delivery of active chemotherapeutic agents with superior selectivity and efficiency.
First Page
10648
Last Page
10661
Recommended Citation
APA Citation
Kordy, A.
Arafa, K.
Dawood, S.
Abdellatif, A.
&
El-Sherbiny, I.
(2025). Actively targeted hyperbranched metal organic framework-based core-shell nanocarriers for the treatment of breast cancer. Journal of Materials Chemistry B, 13(34), 10648–10661.
https://doi.org/10.1039/d5tb00505a
MLA Citation
Kordy, Amr, et al.
"Actively targeted hyperbranched metal organic framework-based core-shell nanocarriers for the treatment of breast cancer." Journal of Materials Chemistry B, vol. 13, no. 34, 2025, pp. 10648–10661.
https://doi.org/10.1039/d5tb00505a