14,441 Genomics-Based Validated Automated Comprehensive Clinicopathologic Correlations for Myeloid Neoplasms

Fifth Author's Department

Institute of Global Health & Human Ecology

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https://doi.org/10.1038/s41597-025-06284-y

All Authors

Ahmed Elsafty Yomna Ahmed Taher F. Halawa Shaoguang Li Samir N. Shamma Dongguang Li Elena Agranovsky Ahmed Soliman Howida Talaat Mohamed Montaser Omar Elnady Deyaa Elnady Mohamed Mahmoud Moustafa Nourhan Ibrahim Maryana Gumenyak Yasmin Soliman Samah Ali Elshaimaa Abdelrahman Hatem M.S. Alahwal Ahmed S. Barefah Ashraf Abdelghany Sherif Ammar Nermeen Abdel-Haleem Osama Abdel-Kareem Naglaa Husein Maha M. Sakr Heba Allah E. AbdElrhman Menatalla Nadim

Document Type

Research Article

Publication Title

Scientific Data

Publication Date

12-1-2025

doi

10.1038/s41597-025-06284-y

Abstract

The dataset (Elsafty_Reports_of_Myeloid_Neoplasms_2024) consists of 14,441 comprehensive clinicopathologic correlations (CPCs) for myeloid neoplasms (MN) with corresponding laboratory results. Specialized online platform utilizing these laboratory results automatically generated the diagnostic and prognostic CPCs. These results include complete blood counts (CBC), peripheral blood smear (PBS) findings, blast/promyelocyte count with dysplasia screening by flow cytometry, and molecular results by NGS/PCR. Two Hematopathologists, who performed the CBC and PBS review, collected their 10,794 real-world reports of cases served in Egypt with molecular studies performed in the USA and Europe. These newly-diagnosed cases included 243 chronic myeloid leukemia (CML) cases with 257 mutations/aberrations; 4,567 non-CML MN cases with 7,883 Tiers I/II mutations/aberrations, amino acid changes, and allele frequencies; and 5,984 benign/inconclusive cases with negative NGS for myeloid mutations/aberrations in 66 DNA/RNA genes. Additionally, there are 3,647 CPCs with synthetic genomics simulating all new/follow-up CML cases and complex/rare non-CML MN cases. Stringent validation by 51 international professors/consultants/specialists from multiple medical centres confirmed 100% medical and clerical accuracy, referencing the WHO 5th edition and relevant esteemed publications.

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