Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose-Brain Drug Delivery

Second Author's Department

Chemistry Department

Fifth Author's Department

Chemistry Department

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https://doi.org/10.1021/acs.molpharmaceut.3c00588

All Authors

Esraa Taha, Amro Shetta, Samia A. Nour, Marianne J. Naguib, Wael Mamdouh

Document Type

Research Article

Publication Title

Molecular Pharmaceutics

Publication Date

3-4-2024

doi

10.1021/acs.molpharmaceut.3c00588

Abstract

The intranasal route has proven to be a reliable and promising route for delivering therapeutics to the central nervous system (CNS), averting the blood-brain barrier (BBB) and avoiding extensive first-pass metabolism of some drugs, with minimal systemic exposure. This is considered to be the main problem associated with other routes of drug delivery such as oral, parenteral, and transdermal, among other administration methods. The intranasal route maximizes drug bioavailability, particularly those susceptible to enzymatic degradation such as peptides and proteins. This review will stipulate an overview of the intranasal route as a channel for drug delivery, including its benefits and drawbacks, as well as different mechanisms of CNS drug targeting using nanoparticulate drug delivery systems devices; it also focuses on pharmaceutical dosage forms such as drops, sprays, or gels via the nasal route comprising different polymers, absorption promoters, CNS ligands, and permeation enhancers.

First Page

999

Last Page

1014

Comments

Review. Record derived from SCOPUS.

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