Analytical modelling and numerical simulations for microfluidic chip enabling accurate sheathless impedance spectroscopy

Third Author's Department

Institute of Global Health & Human Ecology

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https://doi.org/10.1007/s42600-024-00337-8

All Authors

Sameh Sherif, Laila Ziko, Omnia Mahmoud Abdelraheem, Muhammad Elgamal, Yehya H. Ghallab, Yahya Ismail

Document Type

Research Article

Publication Title

Research on Biomedical Engineering

Publication Date

3-1-2024

doi

10.1007/s42600-024-00337-8

Abstract

Purpose: The primary objective is to develop a straightforward and precise microfluidic impedance spectroscopy system that does not require additional focusing devices or forces that directly affect the dielectric properties of cells. The attainment of this notion can be accomplished through the examination of various classifications of electrode configurations in the process of the imaginary part of complex impedance measurements. Methods: This work gives a comparative analysis of various approaches that eliminate the need for focusing in impedance spectroscopy modules. These methodologies are employed to extract the electrical properties of cells. The main objective of this study is to evaluate the impact of various excitation topologies on the measured impedance. The study encompasses the examination of four distinct configurations of electrodes, which can be categorised into two primary groups: the basic two electrodes arranged in parallel and coplanar fashion and the tetrapolar electrodes with two distinct excitation distributions. Following the distribution of these samples, the study primarily examines the outcomes of the impedance analysis and the variations in current seen among the sensing electrodes in relation to the positioning of the cells. Results: The findings indicate that the diagonal analysis exhibits the lowest variation in impedance as the position of the cell changes. Hence, the utilisation of these setups results in an improved level of precision in measurement when compared to alternative procedures. Conclusion: In conclusion, the findings of this work indicate that the implementation of diagonal electrode configurations in microfluidic impedance spectroscopy can lead to enhanced precision and reliability in the measurement of cell dielectric properties. The discovery holds considerable ramifications for the advancement of cell analysis methodologies.

First Page

165

Last Page

179

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