Funding Sponsor

American University in Cairo

Author's Department

Chemistry Department

Second Author's Department

Chemistry Department

Third Author's Department

Chemistry Department

Fourth Author's Department

Chemistry Department

Fifth Author's Department

Chemistry Department

Find in your Library

https://doi.org/10.1039/d4na00519h

All Authors

Rana R. Haikal, Noha El Salakawy, Alaa Ibrahim, Shaimaa L. Ali, Wael Mamdouh

Document Type

Research Article

Publication Title

Nanoscale Advances

Publication Date

7-17-2024

doi

10.1039/d4na00519h

Abstract

Antimicrobial resistance (AMR) has become an immense threat to public health leading to an urgent need for development of new technologies to tackle such a challenge. Plant-based drugs, specifically essential oils (EOs) and plant extracts, have shown significant potential as effective green antimicrobial agents. However, they suffer from high volatility and low thermal stability resulting in their inefficient utilization in commercial settings. Among the various nanoencapsulation technologies reported, metal-organic frameworks (MOFs) have been recently investigated as potential nanocarriers of EOs in attempt to enhance their stability. Herein, we report the utilization of Zn-ascorbate MOF for the encapsulation of marjoram essential oil (MEO) with synergistic antioxidant and antibacterial activities. The prepared composite was thoroughly characterized via a number of techniques and its antibacterial performance was investigated against various strains of Gram-negative and Gram-positive bacteria. The results demonstrated that the antioxidant activity originated from the ascorbic acid ligand (l-Asc), while the antibacterial activity originated from Zn2+ ions as well as encapsulated MEO.

First Page

4664

Last Page

4671

Comments

Article. Record derived from SCOPUS.

Download
Find this item online

Included in

Chemistry Commons

Share

COinS