Alpinia katsumadai seed from a condiment to ethnomedicine to nutraceutical, a comprehensive review of its chemistry and health benefits

Second Author's Department

Biology Department

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https://doi.org/10.1016/j.jtcme.2024.11.010

All Authors

Alaadin E. El-Haddad, Lereen khaled, Mohamed A. Farag

Document Type

Research Article

Publication Title

Journal of Traditional and Complementary Medicine

Publication Date

1-1-2024

doi

10.1016/j.jtcme.2024.11.010

Abstract

From a traditionally used spice to a highly valued therapeutic plant with many biological effects, Alpinia katsumadai Hayata seed (AKS) is widely used as a functional food or nutraceutical. In folk medicine, AKS has been used as an anti-emetic and for gastric disorders. Up to 2024, no comprehensive review summarizing the mode of action of AKS phytoconstituents although large number of studies. This review focuses on food applications, extraction and isolation methods, as well as chemical characterization of AKS phytoconstituents. The ethnopharmacological uses and pharmacological activities of AKS extracts and their isolates were discussed which may maximize AKS use in nutraceuticals. Data were collected using Google Scholar, PubMed, Web of Science, and bibliographic databases of previously published articles. Phytochemical studies have reported more than 153 phytoconstituents belonging to diarylheptanoids and terpenoids in addition to kavalactones, flavonoids, and phenylbutanoids. Bioassays revealed that AKS extracts and their isolates exhibit a wide range of bioactivities such as anti-emetic, antidiabetic, antiviral, anticancer, anti-inflammatory, and digestive system protective effects. This review can provide a reference for further research on AKS for inclusion in nutraceuticals. In addition, new formulations should be explored to improve constituents’ bioavailability and biological effects, alongside elucidation of the underlying action mechanisms.

Comments

Review. Record derived from SCOPUS.

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