The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds
Funding Number
01DL20003
Funding Sponsor
Arab-German Young Academy of Sciences and Humanities
Second Author's Department
Institute of Global Health & Human Ecology
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https://doi.org/10.3390/pharmaceutics16020229
Document Type
Research Article
Publication Title
Pharmaceutics
Publication Date
2-1-2024
doi
10.3390/pharmaceutics16020229
Abstract
This review is concerned with chronic wounds, with an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) and its underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosan NPs, and polymeric micelles) that can further potentiate the antimicrobial photodynamic effect are discussed. This review also delves into the role of photoactive electrospun nanofibers, either in their eluting or non-eluting mode of action, in microbial eradication and accelerating the healing of wounds. Synergic strategies to augment the PDT-mediated effect of photoactive nanofibers are reviewed.
Recommended Citation
APA Citation
Abdel Khalek, M.
Abdelhameed, A.
&
Abdel Gaber, S.
(2024). The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds. Pharmaceutics, 16(2),
10.3390/pharmaceutics16020229
https://fount.aucegypt.edu/faculty_journal_articles/5997
MLA Citation
Abdel Khalek, Mohamed A., et al.
"The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds." Pharmaceutics, vol. 16,no. 2, 2024,
https://fount.aucegypt.edu/faculty_journal_articles/5997
Comments
Review. Record derived from SCOPUS.