Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal
Funding Sponsor
Kingston University
Author's Department
Chemistry Department
Second Author's Department
Chemistry Department
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https://doi.org/10.1016/j.ijpharm.2021.121309
Document Type
Research Article
Publication Title
International Journal of Pharmaceutics
Publication Date
1-1-2021
doi
10.1016/j.ijpharm.2021.121309
Abstract
In the cosmeceutical field, it is essential to develop topical delivery systems which would allow drugs to create a depot and permeate within the skin. The aim of the present study was to develop composite nanofibers of polyvinyl alcohol/quercetin/essential oils using the electrospinning technique, and assess their efficiency in acne alleviation. Quercetin was chosen due to its anti-inflammatory, anti-oxidant, and antibacterial activities. Nanofibers were characterized for their morphology, ex-vivo deposition/permeation, physical/mechanical integrity, thermal properties, and chemical characteristics. In addition, the anti-bacterial efficacy was tested on Propionibacterium acne (P. acne), and a cytotoxicity assay was carried out. Lastly, an experimental clinical trial was conducted on acne patients, where the percentage reduction of inflammatory, non-inflammatory and total acne lesions was taken as evaluation criterion. Results showed that quercetin was successfully loaded into the nanofibers which were homogenously dispersed. They showed a reasonable skin deposition percentage of 28.24% ± 0.012, a significantly higher antibacterial efficacy against Propionibacterium acne than quercetin alone, and were utterly safe on skin fibroblastic cells. Upon clinical examination on acne patients, the nanofibers showed 61.2%, 14.7%, and 52.9% reduction of inflammatory, comedonal, and total acne lesions respectively, suggesting a promising topical anti-acne delivery system.
First Page
1
Last Page
14
Recommended Citation
APA Citation
Amer, S.
Mamdouh, W.
Nasr, M.
ElShaer, A.
...
(2021). Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal. International Journal of Pharmaceutics, 612, 1–14.
10.1016/j.ijpharm.2021.121309
https://fount.aucegypt.edu/faculty_journal_articles/2447
MLA Citation
Amer, Sandra Sherif, et al.
"Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal." International Journal of Pharmaceutics, vol. 612, 2021, pp. 1–14.
https://fount.aucegypt.edu/faculty_journal_articles/2447