Cannabis Use and Electrocardiographic Myocardial Injury
Author's Department
Institute of Global Health & Human Ecology
Find in your Library
https://doi.org/10.1016/j.amjcard.2021.03.058
Document Type
Research Article
Publication Title
The American journal of cardiology
Publication Date
5-25-2021
doi
10.1016/j.amjcard.2021.03.058
Abstract
Multiple observational studies have demonstrated an association with cannabis use and acute myocardial infarction, especially among young adults. However, little is known about the connection with subclinical or electrocardiographic myocardial injury. We hypothesized that cannabis use would be associated with an increased risk of myocardial injury as defined by the cardiac infarction and/or injury score (CIIS). This analysis included 3,634 (age 48.0 ± 5.9 years, 47.1% male, 68.7% Caucasians) participants from the Third National Health and Examination Survey. Cannabis use was defined by self-report. Those with history of cardiovascular disease were excluded. Myocardial injury was defined as electrocardiographic CIIS ≥ 10. Multivariable logistic regression was used to examine the association between cannabis use and myocardial injury. The consistency of this association was tested among subgroups stratified by race, gender, tobacco smoking status, and comorbidities. About 26.0% (n = 900) of participants were ever-cannabis users and 15.5% (n = 538) had myocardial injury. In a model adjusted for potential confounders, ever-cannabis users had 43% increased odds of myocardial injury compared to never users (Odds ratio (95% confidence interval): 1.43 (1.14, 1.80); p = 0.002). This association was stronger among participants with a history of hypertension versus those without (Odds ratio (95% confidence interval): 1.83 (1.36, 2.47) vs 1.17 (0.83, 1.64), respectively; interaction p value 0.04). Cannabis use is associated with an increased risk of myocardial injury among those without cardiovascular disease with effect modification by co-existent hypertension. These novel findings underscore the harmful effects of cannabis use on cardiovascular health and also merit a personalized risk assessment when counseling patients with hypertension on its use.
First Page
100
Last Page
104
Recommended Citation
APA Citation
Skipina, T. M.
Upadhya, B.
&
Soliman, E. Z.
(2021). Cannabis Use and Electrocardiographic Myocardial Injury. The American journal of cardiology, 151([not provided]), 100–104.
10.1016/j.amjcard.2021.03.058
https://fount.aucegypt.edu/faculty_journal_articles/2308
MLA Citation
Skipina, Travis, et al.
"Cannabis Use and Electrocardiographic Myocardial Injury." The American journal of cardiology, vol. 151,no. [not provided], 2021, pp. 100–104.
https://fount.aucegypt.edu/faculty_journal_articles/2308