Clarification of Arachidonic Acid Metabolic Pathway Intricacies
Author's Department
Chemistry Department
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https://doi.org/10.1021/acsomega.1c01952
Document Type
Research Article
Publication Title
ACS omega
Publication Date
6-29-2021
doi
10.1021/acsomega.1c01952
Abstract
Surrounding inflammation activates phospholipase A, which cleaves and releases arachidonic acid (ARA) from cell membranes. The four cis double bonds are instrumental in ARA susceptibility to oxidation, resulting in the generation of numerous bioactive metabolites of critical importance for the immune system, namely inflammation in response to pathogens, resolution of inflammation, wound healing, and mood and energy balance. The ARA metabolism steps are replete with intricacies, deterring researchers from identifying targets, which could be useful in modulating the synthesis of ARA metabolites toward exclusive protection of the host from pathogens, endogenous excessive danger signals, pain, inflammation, stress, and anxiety disorders. While ARA metabolic pathways are reasonably defined, it was deemed mandatory to fully clarify the flow and direction of protons, electrons, and oxygen atoms and the intricacies behind formation and breakage of double bonds and cyclic structures. This in-depth novel information will perfect the development of strategies and drugs aimed at counteracting inflammation and promoting healing.
First Page
15559
Last Page
15563
Recommended Citation
APA Citation
Tallima, H.
(2021). Clarification of Arachidonic Acid Metabolic Pathway Intricacies. ACS omega, 6(24), 15559–15563.
10.1021/acsomega.1c01952
https://fount.aucegypt.edu/faculty_journal_articles/2294
MLA Citation
Tallima, Hatem
"Clarification of Arachidonic Acid Metabolic Pathway Intricacies." ACS omega, vol. 6,no. 24, 2021, pp. 15559–15563.
https://fount.aucegypt.edu/faculty_journal_articles/2294