Effects of Aging on the Myelination of the Optic Nerve in Rats

Author's Department

Biology Department

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https://www.tandfonline.com/doi/full/10.1080/00207454.2018.1529670

All Authors

Hamdino Attia; Medhat Taha; Ahmed Abdellatif

Document Type

Research Article

Publication Title

International Journal of Neuroscience

Publication Date

9-30-2018

doi

10.1080/00207454.2018.1529670

Abstract

Aim of the study: Cognitive decline due to aging is most probably the result of changes in the white matter in the central nervous system (CNS) and/or demyelination. Material and methods: We used electron microscopic analysis of the morphological changes in aging rats’ optic nerves as an easily accessible part of the CNS. Results: Several age changes were observed in aging rats (36 months) vs. young adult rats (6 months), namely degeneration of axons, decreased packing density and morphological alterations of myelination, including the ballooning of some myelin sheaths, separation of myelin lamellae and degenerative changes in the oligodendrocytes population. Conclusion: Cognitive decline related to aging may occur in part due to the disturbed myelination of axons in CNS white matter.

First Page

320

Last Page

324

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