Title

Nanoparticle-based detection of cancer-associated RNA

Author's Department

Chemistry Department

Find in your Library

https://doi.org/10.1002/wnan.1266

Document Type

Research Article

Publication Title

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Publication Date

1-1-2014

doi

10.1002/wnan.1266

Abstract

According to the World Health Organization (WHO), cancer cases are expected to increase globally by 57% over the coming two decades. A critical factor in the management of cancer is early detection using highly sensitive diagnostic techniques. RNAs play a vital role in cancer pathogenesis. The detection of aberrant and/or abnormally expressed RNA has been reported in several cancers. Nanoparticle-based assays have been shown to have enhanced specificity and sensitivity as compared with conventional methods. In addition, nanoparticles have enabled the development of new diagnostic strategies. This review covers nanoparticle-based techniques used for the detection of mRNA and micro-RNA associated to different cancers. © 2014 Wiley Periodicals, Inc.

First Page

384

Last Page

397

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