The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks

Funding Sponsor

Medical Research Council

Author's Department

Biology Department

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Document Type

Research Article

Publication Title

Molecular and Cellular Oncology

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© 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Andreas Kakarougkas, Jessica A Downs, and Penny A Jeggo. Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.1 We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required.2 Failure to activate transcriptional suppression impedes a rapid DSB repair process.

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