Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles
Author's Department
Chemistry Department
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https://doi.org/10.1155/2017/3528295
Document Type
Research Article
Publication Title
Journal of Nanomaterials
Publication Date
1-1-2017
doi
10.1155/2017/3528295
Abstract
© 2017 Rania Ibrahim Shebl et al. Unmodified magnetic nanoparticles (MNPs) lack antibacterial potential. We investigated MNPs surface modifications that can impart antibacterial activity. Six MNPs species were prepared and characterized. Their antibacterial and antibiofilm potentials, surface affinity, and cytotoxicity were evaluated. Prepared MNPs were functionalized with citric acid, amine group, amino-propyl trimethoxy silane (APTMS), arginine, or oleic acid (OA) to give hydrophilic and hydrophobic MNPs with surface charge ranging from -30 to +30 mV. Prepared MNPs were spherical in shape with an average size of 6-15 nm. Hydrophobic (OA-MNPs) and positively charged MNPs (APTMS-MNPs) had significant concentration dependent antibacterial effect. OA-MNPs showed higher inhibitory potential against S. aureus and E. coli (80%) than APTMS-MNPs (70%). Both particles exhibited surface affinity to S. aureus and E. coli. Different concentrations of OA-MNPs decreased S. aureus and E. coli biofilm formation by 50-90%, while APTMS-MNPs reduced it by 30-90%, respectively. Up to 90% of preformed biofilms of S. aureus and E. coli were destroyed by OA-MNPs and APTMS-MNPs. In conclusion, surface positivity and hydrophobicity enhance antibacterial and antibiofilm properties of MNPs.
Recommended Citation
APA Citation
Shebl, R.
Farouk, F.
&
Azzazy, H.
(2017). Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles. Journal of Nanomaterials, 2017,
10.1155/2017/3528295
https://fount.aucegypt.edu/faculty_journal_articles/1229
MLA Citation
Shebl, Rania Ibrahim, et al.
"Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles." Journal of Nanomaterials, vol. 2017, 2017,
https://fount.aucegypt.edu/faculty_journal_articles/1229