Title

A computational model for dilated cardiomyopathy: morphology and electromechanics

Abstract

The aim of this thesis was to develop a computational model that can simulate the key changes in morphology and electrophysiology that are observed in patients of dilated cardiomyopathy (DCM), and to predict the associated diastolic (mechanical) dysfunction. The computational model herein developed was then applied to an in-silico study of cardiac resynchronization therapy (CRT) to assess its potential utility as an investigative tool in clinical research. Specifically, the DCM model herein developed captures three beats of a human heart (male, in his mid-twenties). The case of DCM represented herein also possesses a left bundle branch block (LBBB). LBBB alters the sequence of electrical activation across the cardiac domain, leading to ventricular asynchrony and hampering cardiac systolic and diastolic functions, as is typical in DCM patients. A methodology for the cardiac growth and remodeling (morphing) was thus developed to represent the dilation of ventricles of DCM patients, based on an application of thermal expansion techniques. Then, a hierarchically coupled electromechanical model was set up to simulate the effect of DCM and LBBB on cardiac function. Predictions from our model were then compared to the literature and to clinical data that was made available to us by the Aswan Heart Centre (AHC) as part of a collaborative research project between the Magdi Yacoub Foundation (MYF) and the American University in Cairo (AUC). The computational platform used in this work is the SIMULIA Living Heart Human Model (LHHM), which is associated with the finite element solver ABAQUS. The LHHM is presently only available to members of the Living Heart Project (LHP). The proposed methodologies have fairly produced relevant models representing LBBB and DCM, which was successfully validated in comparison to the literature and to clinical data.

Department

Mechanical Engineering Department

Degree Name

MS in Mechanical Engineering

Graduation Date

2-1-2019

Online Submission Date

January 2019

First Advisor

ElKhodary, Khalil

Committee Member 1

El Morsy, Mohamed

Committee Member 2

Badran, Mohamed

Document Type

Master's Thesis

Extent

119 p.

Rights

The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy.

IRB

Not necessary for this item

Comments

My sincere thanks goes to all the research team in Magdi Yacoub Foundation for their collaboration and support in this research work.

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