Abstract

Cancer is one of the rapidly growing leading causes of death worldwide where combinational chemotherapy is the most used strategy to control it. Drug delivery constitutes a major segment in chemotherapeutics including liposomes as a drug delivery system enabling the encapsulation of both hydrophilic and hydrophobic drugs. Recently, liposomes have been recognized as an efficient means for drug delivery of combinational chemotherapy. The aims of this study were to prepare stable liposomal formulations with particle sizes of less than 200 nm and that offer high encapsulation efficiency for oxaliplatin. Subsequently, the use of the developed liposomal system in dual drug loading was investigated using two approaches, oxaliplatin and a chemo-sensitizing agent, and oxaliplatin combined with a chemotherapeutic agent. In addition, the effect of dual drug loading on liposome characterization, in-vitro release profile and cytotoxic efficiency were investigated. In this study, all prepared liposomal formulations were highly stable upon long term storage. The dual chemotherapeutic loaded liposomal formulation demonstrated a significantly enhanced in-vitro cytotoxic efficiency, and DNA damage induction.

Department

Chemistry Department

Degree Name

MS in Chemistry

Date of Award

6-1-2016

Online Submission Date

March 2016

First Advisor

Shoeib, Tamer

Committee Member 1

Kakarougkas, Andreas

Committee Member 2

El Gazayerly, Omaima

Document Type

Thesis

Extent

90 p.

Rights

The author retains all rights with regard to copyright. The author certifies that written permission from the owner(s) of third-party copyrighted matter included in the thesis, dissertation, paper, or record of study has been obtained. The author further certifies that IRB approval has been obtained for this thesis, or that IRB approval is not necessary for this thesis. Insofar as this thesis, dissertation, paper, or record of study is an educational record as defined in the Family Educational Rights and Privacy Act (FERPA) (20 USC 1232g), the author has granted consent to disclosure of it to anyone who requests a copy.

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Approval has been obtained for this item

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