Title

Comparative study on radiolabeling and biodistribution of core-shell silver/polymeric nanoparticles-based theranostics for tumor targeting

Author's Department

Chemistry Department

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https://doi.org/10.1016/j.ijpharm.2017.06.044

Document Type

Research Article

Publication Title

International Journal of Pharmaceutics

Publication Date

8-30-2017

doi

10.1016/j.ijpharm.2017.06.044

Abstract

© 2017 A simple and rapid method for radiolabeling of three types of Ag NPs has been performed using 125I isotope, with high labeling yields, >90% without disturbing the optical properties. All the factors affecting labeling yield were studied. In order to monitor the in-vivo tissue uptake of radiolabeled Ag NPs using γ-rays, Ag-based radioiodo-NPs with a maximum labeling yield were intravenously injected in normal and solid tumor bearing mice. The preliminary biodistribution study revealed that this new radioiodo-NPs have a high affinity to be localized in the tumor site for a long period of time. The reported highly efficient method provides new radiolabeled Ag-based NPs as tumor-specific agents for both diagnostic and therapeutic applications.

First Page

123

Last Page

133

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