Dietary Guduchi (Tinospora cordifolia) enhanced the growth performance, antioxidative capacity, immune response and ameliorated stress-related markers induced by hypoxia stress in Nile tilapia (Oreochromis niloticus)

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Center for Applied Research on the Environment & Sustainability

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Mohammed F El Basuini, Islam I Teiba, Shimaa A Shahin, Mona M Mourad, Mohamed A A Zaki, Eman M H Labib, Mohamad Nor Azra, Hani Sewilam, M F El-Dakroury, Mahmoud A O Dawood

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Research Article

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Nile tilapia contributes to the aquaculture sector as the second most cultivated fish species due to its high value as a source of food and business [1,2]. Tilapia can tolerate a wide range of farming conditions, making it a successful candidate for semi-intensive and intensive aquaculture systems [[3], [4], [5]]. However, growing fish under stressful conditions led to severe impacts on the health condition, metabolic and physiological responses [6]. Indeed, fluctuations in the dissolved oxygen are usually detected in the water of tilapia farms resulting from the high temperature, algal blooms, lack of water exchange, high accumulation of organic matter and feces, and leftover pellets [7,8]. Severe hypoxia conditions usually induce oxidative stress, inflammation, immunosuppression, and metabolic dysfunctions [9,10]. It has been illustrated that the inclusion of dietary medicinal herbs could positively enhance the physiological status leading to high tolerance against fluctuations in the water quality, including hypoxia stress

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