Sensitive Determination of SARS-COV-2 and the Anti-hepatitis C Virus Agent Velpatasvir Enabled by Novel Metal-Organic Frameworks
Funding Sponsor
American University in Cairo
Author's Department
Energy Materials Laboratory
Second Author's Department
Energy Materials Laboratory
Fourth Author's Department
Physics Department
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https://doi.org/10.1021/acsomega.1c04525
Document Type
Research Article
Publication Title
ACS Omega
Publication Date
10-12-2021
doi
10.1021/acsomega.1c04525
Abstract
Herein, we report on the electrochemical determination of velpatasvir (VLP) as the main constituent of Epclusa, a SARS-COV-2 and anti-hepatitis C virus (HCV) agent, using a novel metal-organic framework (MOF). The NH2-MIL-53(Al) MOF was successfully modified with 5-bromo-salicylaldehyde to synthesize 5-BSA=N-MIL-53(Al) MOF. The synthesized MOF has been characterized using Fourier transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy, cyclic voltammetry, square wave voltammetry, and electrochemical impedance spectroscopy. The modified MOF showed higher electrochemical activity and response than the bare NH2-MIL-53(Al) MOF. Compared to the bare carbon paste electrode (CPE), the 5-BSA=N-MIL-53(Al)/CPE platform was shown to enhance the electrochemical oxidation and detection of the anti-SARS-COV-2 and anti-HCV agent. Under optimized conditions, the 5-BSA=N-MIL-53(Al)/CPE platform showed a linear range of 1.11 × 10-6 to 1.11 × 10-7 and 1.11 × 10-7 to 25.97 × 10-6 M Britton-Robinson buffer (pH 7) with a detection limit and limit of quantification of 8.776 × 10-9 and 2.924 × 10-8 M, respectively. Repeatability, storage stability, and reproducibility in addition to selectivity studies and interference studies were conducted to illustrate the superiority of the electrode material. The study also included a highly accurate platform for the determination of VLP concentrations in both urine and plasma samples with reasonable recovery.
First Page
26791
Last Page
26798
Recommended Citation
APA Citation
Saleh, M.
Mohamed, M.
Shahat, A.
&
Allam, N.
(2021). Sensitive Determination of SARS-COV-2 and the Anti-hepatitis C Virus Agent Velpatasvir Enabled by Novel Metal-Organic Frameworks. ACS Omega, 6(40), 26791–26798.
10.1021/acsomega.1c04525
https://fount.aucegypt.edu/faculty_journal_articles/2755
MLA Citation
Saleh, Mahmoud A., et al.
"Sensitive Determination of SARS-COV-2 and the Anti-hepatitis C Virus Agent Velpatasvir Enabled by Novel Metal-Organic Frameworks." ACS Omega, vol. 6,no. 40, 2021, pp. 26791–26798.
https://fount.aucegypt.edu/faculty_journal_articles/2755