Stimuli-Responsive Amphiphilic Pillar[ n]arene Nanovesicles for Targeted Delivery of Cancer Drugs

Funding Number

PIP 1122010010013901

Funding Sponsor

Consejo Nacional de Investigaciones Científicas y Técnicas

Author's Department

Mechanical Engineering Department

Third Author's Department

Chemistry Department

Fourth Author's Department

Chemistry Department

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Document Type

Research Article

Publication Title

ACS Omega

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Cancer chemotherapeutics face several challenges, including uncontrollable drug release, off-target toxic effects, and poor bioavailability. Recently, supramolecular nanovesicles, such as calix[n]arenes (CXs), cyclodextrins (CDs), cucurbiturils (CBs), and pillar[n]arenes (PRs), have attracted attention as potential smart nanocarriers for chemotherapeutics because of their exceptional cavities that can achieve high encapsulation capacity and accommodate both hydrophilic and hydrophobic drugs. In addition, they can be functionalized with different stimuli-responsive groups, which facilitate controlled drug release. Supramolecular nanovesicles, loaded with drugs and decorated with stimuli-responsive targeting moieties, are designed by either host-guest complexation or self-assembly of amphiphilic cavitands. Pillar[n]arenes, in particular, are novel supramolecular host molecules that have recently been employed in cancer targeted drug delivery because of their symmetric pillar-shaped structure, simplicity of functionalization, and biocompatibility. This review summarizes state-of-the-art strategies for developing single or multiple stimuli-responsive pillar[n]arene nanovesicles for effective cancer treatment.

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