Abstract

FOXO1 is a transcription factor which plays a role in organ development and tumorigenesis, where it acts mainly as a tumor suppressor by controlling cell proliferation, cell cycle progression, and programmed cell death via variable mechanisms. In hepatocellular carcinoma (HCC), FOXO1 has been shown to be downregulated in liver tissues, and the lower expression has been correlated with poor prognosis. In natural killer cells, FOXO1 has been shown to regulate cell maturation and thus its activity. Studies show that non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are contributing to the immune response regulation and disease pathogenesis in HCC. Various studies have identified miRNAs as regulators of the cytolytic activity of natural killer (NK) cells against cancers. Thus, the interplay of non-coding RNAs and FOXO1 may have a crucial role in HCC pathogenesis. Accordingly, the focus of our study was to investigate whether non-coding RNAs and FOXO1 regulate one another in a regulatory loop. The objective of our study was to examine non-coding RNAs as upstream regulators of FOXO1and to understand the impact of FOXO1 on downstream non-coding RNAs.

School

School of Sciences and Engineering

Department

Biotechnology Program

Degree Name

PhD in Applied Science

Graduation Date

Spring 6-18-2025

Submission Date

5-25-2025

First Advisor

Dr. Ahmed Moustafa

Second Advisor

Dr. Ahmed Ihab Abdelaziz

Third Advisor

Dr. Nada El-Ekiaby, Dr. Injie Fawzy

Committee Member 1

Dr. Ahmed Abdellatif

Committee Member 2

Dr. Mohamed Sallama

Committee Member 3

Dr. Khaled Amer, Dr. Imam Waked

Extent

73p.

Document Type

Doctoral Dissertation

Institutional Review Board (IRB) Approval

Not necessary for this item

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Available for download on Tuesday, May 25, 2027

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